Sepsis remains a leading cause of preventable mortality and critical illness, making timely recognition and evidence-based management essential to improving patient outcomes. This micro-course equips Advanced Practice Nurses with the clinical knowledge and decision-making strategies needed to address common challenges in sepsis care. Grounded in the 2026 Surviving Sepsis Campaign guidelines, the course translates current evidence into practical approaches for recognizing sepsis, guiding treatment decisions, and delivering timely, effective care across clinical settings.